Expression of 12 proteins was found to be upregulated more than 2 folds, including squamous cell carcinoma antigen (SCCA), cytokeratin14, cytokeratin17, and RhoGDI 1, or downregulated (e.g., cytokeratin15 and calreticulin) in the psoriasis group compared with normal skin [50]. The gene discussed is SERPINB3; the disease is psoriasis.