Identified in Additional file 1: Table S1, Lyric (also known as Metadherin or astrocyte-elevated gene 1 (AEG-1)) was first identified as a HIV-1 inducible gene and has been suggested to play a role in a positive-feedback loop promoting HIV-1 replication [15] and has also been implicated in HIV-associated neuropathy [16, 15]. The gene discussed is MTDH; the disease is neuropathy.