To evaluate the role of mutant p53 and Fascin in colorectal cancer progression, we collected a cohort of 75 colorectal adenocarcinoma patients and determined the expression of p53 protein and Fascin by immunohistochemistry, as well as the p53 mutation status by direct DNA sequencing (Fig. 1a). The gene discussed is TP53; the disease is colorectal adenocarcinoma.