We have used RNA-seq analysis to define genes differentially expressed between APC subpopulations that could (CD1c+, SLAN+, CD14+ monocytes) and could not induce latent infection (pDC), and identified genes mediating cell adhesion, T-cell activation, immune checkpoints (IC) and regulation of apoptosis as important pathways differentially upregulated in the APC that are able to induce latent infection. The gene discussed is CD14; the disease is disease arising from reactivation of latent virus.