On the other hand, treatment of the human GBM cell line U343 with RA induced expression of different genes (HOXB7, FGF2, VEGF, and IL-8) that may contribute to tumour cell proliferation, hypoxia, and angiogenesis, thereby potentially limiting the therapeutic efficacy of RA [11]. The gene discussed is CXCL8; the disease is glioblastoma.