Endonuclease G (EndoG) and sirtuin2 (SIRT2) have been identified contributing to α synuclein toxicity while vacuolar protein sorting 35 (VPS35), glucose phosphate isomerase 1 (GPI), tumor necrosis factor receptor-associated protein 1 (TRAP1), nuclear factor erythroid 2-related factor 2 (Nrf2), Rab1a, Rab8, histone deacetylase 6 (HDAC6), PTEN induced putative kinase 1 (Pink1), Cu/Zn superoxid Dismutase (SOD), methionine sulfoxide reductase A (MSRA), parkin as well as heat shock cognate 70-kd protein (Hsp70) could intervene PD progression [25–37]. The gene discussed is NFE2L2; the disease is Parkinson disease.