More recently, Kalume et al. documented the profound disruption of sleep during the photophase and impaired homeostatic sleep rebound in mice heterozygous for a Scn1a null allele, a model of Dravet syndrome (DS) ─ a severe, childhood-onset and often refractory epilepsy syndrome [28]. Here, SCN1A is linked to encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.