This is confirmed experimentally by our data that PD-1 pathway blockade could largely restore the T cell proliferation and secretion of cytokines in PD-L1 expressing EBV+DLBCL and ABC-DLBCL versus PD-L1-negative EBV-DLBCL and GCB-DLBCL. Here, CD274 is linked to aneurysmal bone cyst.