Considering that the expression of PD-1 was elevated on the T cells of the DLBCL tissues and the expression of PD-L1 was elevated in certian subtypes of DLBCL specimens (ABC-DLBCL and EBV+DLBCL) and cell lines, we speculated that disruption of PD-1/PD-L1 interaction might restore normal function of T cells. The gene discussed is CD274; the disease is diffuse large B-cell lymphoma.