mTOR could act as an important regulator for 4E-BP1 phosphorylation, and p-4E-BP1 has been frequently found and/or indicated as a prognostic predictor for poor survival in different cancers such as breast cancer [26], nasopharyngeal carcinoma [27], hilar cholangiocarcinoma [28], gastric cancer [29], and lung cancer [30, 31]. This evidence concerns the gene EIF4EBP1 and hilar cholangiocarcinoma.