Despite the fact that bone marrow (BM), as a special source for liquid biopsy [15], is by far more accessible than tumor samples (BM aspirates are routinely obtained at different time points in current high risk neuroblastoma studies, e.g. HR-NBL1) and that it is a common organ for disseminated tumor cells (DTCs) in NB [16], the expression profile of enriched DTCs was studied so far from one group [17]. This evidence concerns the gene NBL1 and neoplasm.