In the multivariate analysis adjusted for these factors, younger age (<65), total number of urinary sediment examinations (≥4), diabetes, a history of pelvic surgery for colon cancer, alpha-1 blocker use, a history of TURP, and SSRI use were demonstrated to be independent indicators for the presence of at least one sperm in urinary sediment. This evidence concerns the gene PSMA6 and malignant colon neoplasm.