SERPINE1 and neoplasm: Multivariate Cox analysis, excluding patients treated with surgery, showed that SERPINE1 expression (HR 1.92, 95%CI 1.03–3.59, p = 0.043) and tumor size (HR 2.39, 95%CI 1.29–4.39, p = 0.005) were independent risk factors for progression-free survival in patients receiving radiotherapy and chemo-radiotherapy as the main treatment option (Table 3).