Interestingly, several negatively-correlated miRNA/mRNA pairs in RA were validated in our study, including miR-19/TLR2, miR-23/TAB3, as well as miR-323 and its target genes GSK3B, BTRC, etc, though the gene expression variation may be less than 2-fold (not shown). Here, TLR2 is linked to rheumatoid arthritis.