Initially, human CD4+ and CD8+ T cells in C4-27z and C4opt-27z CAR cohorts were present in lower numbers in the peripheral circulation in comparison to CD19-27z CAR T cells, suggesting early FRα-specific CAR T cell migration to specific tumor sites (Figure 5C, student t test, p < .01 - .001). This evidence concerns the gene CD4 and neoplasm.