TNF and ovarian carcinoma: C4-27z and C4opt-27z CAR T cells exclusively recognized FRα+ ovarian cancer lines, secreting high levels of Th-1 cytokines, including IFN-γ, IL-2, TNF-α and MIP-1A (Figures 3A–3B, 3F–3G, 3K–3L, 3P–3Q).