Furthermore, significantly increased proliferation (Ki-67 staining) and decreased apoptosis (cleaved caspase 3 staining) were detected in the tumor specimens of mice injected with 4T1/COX-2+ TAMs, while an inverse result was obtained from mice injected with 4T1/COX-2− TAMs, compared with that of mice injected with 4T1/normal TAMs (Figure 2D–2E). Here, PTGS2 is linked to neoplasm.