In a multivariate Cox regression analysis, COX-2+ TAM counts were associated with poor survival prognosis of breast cancer patients (HR = 2.085, p = 0.036), independent of other clinical covariates (Table 2), indicating that COX-2+ TAM is an independent prognostic biomarker for breast cancer outcome, and COX-2 in TAMs may play an important role in breast cancer progression. This evidence concerns the gene PTGS2 and breast cancer.