In concert with our data, we speculate that an over-activation of INPP1, besides increasing the activity and stability of DNA Polymerase α promotes cancer cell replication, stimulates the generation of some second messengers such as diacylglycerol and InsP3 which are important in the activation of protein kinase C, responsible for survival and propagation of proliferation-enhancing stimuli. The gene discussed is INPP1; the disease is cancer.