When HCC cells were cultured under hypoxic conditions of 0.5% O2, NDRG1, a known hypoxia-inducible protein, was induced in all three cell lines, with marked induction observed in Hep3B cells that had undetectable levels of NDRG1 under normoxia (Figure 2A). The gene discussed is NDRG1; the disease is hepatocellular carcinoma.