Since both GSK-3β and Nur77 facilitate β-catenin degradation, and we observed that NDRG1 enhance β-catenin accumulation, we further hypothesized that NDRG1 interaction with GSK-3β and Nur77 may impede β-catenin degradation (allowing nuclear accumulation) in HCC cells. The gene discussed is NR4A1; the disease is hepatocellular carcinoma.