ESR1 and neoplasm: Of note, the ESR1 and GATA3 RPPA-based metagenes known to be associated with ER-positive tumours were significantly correlated with ER status determined by IHC (p = 2.36e−20, p = 1.55e−16 respectively) (Figure 3E,3F), while lymphocyte-specific protein tyrosine kinase (Lck) and spleen tyrosine kinase (Syk) RPPA-based immune-derived metagenes significantly correlated with TILs levels (Lck; R = 0.53, p = 2.44e-15 and Syk; R = 0.62, p = 4.14e−22) (Figure 3G,3H).