The insulin resistance shifted the energy supply to a high concentration of ketone bodies, induced CYP2E1 overexpression, mediated ROS production with iron overload, induced ADH4 overexpression and arachidonic acid peroxidation, induced cellular membrane damage, activated the DNA injury pathway EGR1-ATF3-GADD45G and triggered inflammation. Here, GADD45G is linked to Insulin resistance.