PIK3CA and metastatic malignant neoplasm in the lymph nodes: In our study of a large cohort of Chinese patients who underwent surgery-based multimodal therapy, PIK3CA mutations were associated with a longer RFS on both univariate analysis and multivariate analysis including almost all risk factors for recurrence (pathological subgroup, FIGO stage, lymph node metastasis, parametrial involvement, lymph vascular involvement and deep myometrial invasion).