CLEC4M and infection: Several in vitro studies with WNV and alphaviruses demonstrated a preferential binding of mosquito cell-derived viruses to the dendritic cell-intracellular adhesion molecule (ICAM)-3 grabbing non integrin related (DC-SIGNR) and an enhanced infection of dendritic cells with mosquito cell-derived viruses compared to viruses propagated in mammalian cells [25–28].