Furthermore, mTOR was an independent prognostic factor for DFS (hazard ratio, 2.229; 95% CI, 1.123–4.425; P = 0.022, Table 2) and OS (hazard ratio, 2.033; 95% CI, 1.117–3.701; P = 0.020, Table 3) in the cohort of 148 resected ESCC patients. Here, MTOR is linked to esophageal squamous cell carcinoma.