However, the high expression of PTEN in ESCC patients is significantly different from one with lower expression in the OS and DFS; the patients with PTEN increased expression have more OS and DFS (OS: 32.8 versus 25.2, P < 0.001; DFS: 29.7 versus 20.2, P < 0.001, resp). This evidence concerns the gene PTEN and esophageal squamous cell carcinoma.