SHC1 and early-onset autosomal dominant Alzheimer disease: Significant pathway analysis revealed that the gene expression alterations in endometrial stromal cells were involved in pathways of PTEN (ITGB1, SHC1), TFF (ITGB1, SHC1), ECM (ITGB1, SHC1), ERK (ITGB1, SHC1), integrin (ITGB1, SHC1), pathogenic Escherichia coli infection (ITGB1, TUBB), chemokine signaling pathway (SHC1, VAV3, and GNB2), focal adhesion (ITGB1, SHC1, and VAV3), regulation of cytoskeleton (ITGB1, VAV3, and MYH9), leukocyte transendothelial migration (ITGB1, VAV3), natural killer cell-mediated cytotoxicity (SHC1, VAV3), and Alzheimer's disease (UQCRB, PSEN2) (Table 2).