Interestingly, the disruption of the GARP subunit Vps54 in mice leads to a ‘wobbler’ phenotype, indicative of neurodegenerative disease sharing characteristics of ALS, including progressive motor degeneration and motor neuron loss (Perez-Victoria et al., 2010; Moser et al., 2013). The gene discussed is VPS54; the disease is neurodegenerative disease.