CHFR and cancer: Given the facts that reduced CHFR expression or epigenetic silencing is clearly associated with better clinical responses and even more importantly, improved overall survival following taxane based therapy in a variety of cancers and that the CHFR's PBZ domain is essential for its checkpoint function, we hypothesized that targeting the protein-protein interactions mediated by the CHFR PBZ domain could be exploited as a strategy to increase taxane sensitivity in tumors with high CHFR expression.