CHFR and non-small cell lung carcinoma: To determine the functional relevance of the PBZ domain on taxane resistance in NSCLC, we transfected CHFR deficient CALU-6 cells either with full-length CHFR (pDEST40-wt-CHFR) or PBZ mutant CHFR (pDEST40-CHFR-PBZ*).