To explore whether miRNA dysregulation in lung cancer is involved in TβRII downregulation, we performed miRNA microarray analyses using total RNA from lung adenocarcinoma cell line A549, immortalized human lung epithelial cell lines Beas2B and HPL1A with normal expression of TβRII, lung squamous carcinoma cell line ACC-LC-176 (ACC), and adenocarcinoma cell line VMRC-LCD (VMRC) lacking TβRII expression. The gene discussed is TGFBR2; the disease is lung cancer.