We have observed that there are higher levels of miR-145 and lower levels of c-Myc in the immortalized lung epithelial cell lines HPL1A and Beas2B and the lung cancer cell line A549 with normal expression of TβRII compared with those in lung cancer cell lines ACC-LC-176 and VMRC-LCD lacking TβRII (Fig. 7 and S7). The gene discussed is TGFBR2; the disease is lung cancer.