Since there are higher levels of miR-20a in lung cancer cell lines ACC-LC-176 and VMRC-LCD lacking TβRII expression (Fig. 1A and 1B), we hypothesize that miR-20a downregulation in these cells can decrease tumorigenicity by restoring TβRII expression and TGF-β-mediated tumor suppressor functions. This evidence concerns the gene TGFB1 and neoplasm.