ATP6V1C1 and hepatocellular carcinoma: Moreover, increased ATP6V1C1 subunit expression levels were found to be associated with metastatic potential of tumors [39] and, in agreement with these findings, depletion of ATP6V1C1 subunit by siRNA resulted in the suppression of growth and metastasis in in vitro and in vivo models of hepatocellular carcinoma [40].