Emergency department (ED) hyperglycemia has been observed to be a strong predictor of in-hospital outcomes.1 Stress-induced hyperglycemia (SIH) is common in patients with critical illness, including sepsis, multiple trauma, major surgery, and acute myocardial infarction (AMI).2–5 SIH occurs secondary to an increase in the levels of counter-regulatory hormones (cortisol, catecholamines, glucagon, and growth hormone), which results in increased gluconeogenesis and decreased glycogenolysis. The gene discussed is GCG; the disease is Hyperglycemia.