Previous studies have consistently demonstrated that alpha-blocker classes of antihypertensive medications have protective effects on carbohydrate and lipid metabolism because alpha-blockers may promote peripheral vasodilation and improve insulin sensitivity and glucose uptake.32 However, to the best of our knowledge, no studies have investigated the relationship between alpha-blocker usage and risk of developing NOD in women with hypertension and CAD. This evidence concerns the gene INS and dentatorubral-pallidoluysian atrophy.