Therefore, based on existing validation studies, scores that incorporate CRP and serum albumin (mGPS and GPS) may reflect both the presence of a systemic inflammatory response and a progressive nutritional decline in patients with cancers, and were superior to those based on components of the circulating white cell count (NLR, PLR) or in combination with albumin alone (PNI).Therefore, any further development of inflammation-based prognostic scores to improve the power of prognosis should also include the prototypical acute phase protein CRP. This evidence concerns the gene CRP and cancer.