VEGFA and neoplasm: It has been proposed that elevated levels of CRP, which is produced by hepatocytes in response to inflammatory cytokines, particularly interleukin-6, indicates T-lymphocyte impairment, which reflects compromised cell-mediated immunity and is associated with poor outcome in malignancy.41 On the contrary, CRP levels are directly associated with circulating concentrations of vascular endothelial growth factor, a proangiogenic environment growth factor, allowing unrestrained tumor growth and dissemination.