TTF2 and multinodular goiter: The core binding locus is CAAG, and the missense variant of rs944289 can affect the binding sequence and result in amino acid substitution (valine instead of alanine at codon 339), which can induce multinodular goiter and PTC.46 Similarly, TTF2 located 57 kb downstream to rs965513, and the promoter region included core sequence TTTGT.47 Gene mutation of rs965513 can result in TTF2, lost its function to bind DNA, and unable to stir transcription.48