As a follow-up, this report is the first to show that without Cu overload, exogenous SOD potentiates sub-toxic DSF increasing cell death in two wt p53 human melanoma cell lines differing in their V600E-mutant BRAF status and in mutant p53 R175H SKBR3 breast carcinoma cells overexpressing the EGFR2/Her2 oncogene. Here, SOD1 is linked to melanoma.