Since extracellular superoxide anions and H2O2 have been implicated in stimulation of proliferation [35–37], this report investigated whether exogenous addition of SOD [35] or glucose oxidase [38, 39] a source of limited amounts of H2O2 [38] augment the anti-tumor efficacy of sub-toxic DSF without increasing Cu. Here, SOD1 is linked to neoplasm.