MRGPRD and allergic contact dermatitis: The distribution of instantaneous frequencies of discharge in the SA discharge in Fig 4A is quite similar to that recorded from a) C-mechanoheat sensitive cutaneous nociceptors in response to the pruritic agent cowhage in the mouse [20] and in the monkey [21], b) MrgprA3+ and MrgprD+ neurons in response to injection of chemical pruritogen in mice [16, 19] and unpublished response analyses, and c) the spontaneous discharge of MrgprA3+ neurons innervating an area of allergic contact dermatitis (median IF of 1.0 Hz) [25].