Patients with severe SRBD had the highest BMI, highest CRP and HbA1c, highest BP, and a trend towards higher prevalence of atrial fibrillation, coronary artery disease, myocardial infarction, apoplexy and renal insufficiency, according to the hypothesis that SRBD causes or interacts with cardiovascular and metabolic sequelae. The gene discussed is CRP; the disease is Renal insufficiency.