To further clarify the role of p130Cas in the Gas6-dependent Axl activation and its contribution to ovarian cancer cell interaction with the ECM, SKOV3 cells were transiently transfected with siRNA targeting p130Cas or with a control siRNA, Silenced cells were then starved, and, while plated on FN, cell adhesion was monitored for up to 1 h by live imaging in the presence or absence of Gas6. The gene discussed is AXL; the disease is ovarian cancer.