But some other studies that used inhibitors, knockdown, or mutagenesis methods indicated UCP2 might have many deleterious effects and were involved in pathogenesis of numerous diseases, such as cardiovascular diseases [15], type 2 diabetes mellitus [8], obesity [16], polycystic ovary syndrome (PCOS) [17], and various cancers [18]. The gene discussed is UCP2; the disease is polycystic ovary syndrome.