ABCC6-related research demonstrates the feasibility of translating findings in animal studies to humans; at the same time, it emphasizes the continuous need for thorough and comprehensive studies, for example, studies which investigate not only a single ABCC6 mutation but the whole mutation spectrum to identify risk alleles for CHD and stroke, certainly as many indications exist for the relevance of ABCC6 in these disorders, as well as replication studies. Here, ABCC6 is linked to Stroke.