ABCC6 and Hyperlipoproteinemia type 4: PXE patients with moderately severe type IV hyperlipoproteinemia were screened and it was shown that ABCC6 p.(R1164X) nonsense mutation and the ABCC6 p.(R1268Q) SNP are associated with dyslipidemia, characterized by high plasma triglyceride and low HDL cholesterol [35, 36].