Furthermore, Sema3E/Plexin D1 induces EMT through nuclear localization of Snail and PI3K and ERK/MAPK signaling pathways, which play an important role in the Sema3E/Plexin D1-mediated EMT process in ovarian endometrioid carcinoma cells [151]. The gene discussed is PLXND1; the disease is ovarian endometrioid carcinoma.