ERBB2 and breast neoplasm: For example, Kim et al. reported the co-activation of WDR5 and ER signalling [6]; Yoshimaru et al. demonstrated the crucial role of the WDR5-PHB2 complex in the modulation of ER signalling [7]; and Mungamuri et al. showed the joint effort of WDR5 silencing and chemotherapy in inhibiting the growth of HER2 positive breast tumour cells [8].