In addition, unpublished data report the upregulation of most inflammasome sensor subtypes (NLRP1, NLRP3, NLRP12, NLRC4, AIM2, IFI16, MNDA, and PYHIN1) in the colonic mucosa of active IBD patients, with the double-stranded (ds) DNA responding PYHIN inflammasome subtypes (AIM2 and IFI16) showing the strongest increase. Here, AIM2 is linked to inflammatory bowel disease.