For example, AIM2 could be an attractive candidate as it senses damage-associated molecular patterns, such as cytoplasmic and mitochondrial DNA, which are increased in NASH patients.39 AIM2 could form an NLRP3-independent inflammasome with Pycard and caspase-1, contributing to the pathological features of these liver diseases. The gene discussed is PYCARD; the disease is metabolic dysfunction-associated steatohepatitis.