Pyroptosis is defined as a caspase-1 or caspase-11-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1β and IL-18.25, 26 Therefore, the NLRP3 inflammasome could be a major cause of cell death and inflammation in NASH progression. This evidence concerns the gene IL18 and metabolic dysfunction-associated steatohepatitis.