TGFB1 and Hepatic fibrosis: Because of that and its short half-life in blood (2–5 min), serum HA levels can reflect liver fibrosis stage and were incorporated into a long list of serum noninvasive liver fibrosis markers such as procollagen III N-terminal propeptide (PIIINP), laminin and transforming growth factor beta (TGF-β) [8].