PTEN and melanoma: When crossed with Tyr::CreER mice and tamoxifen is rubbed on their skin, these mice develop benign melanocytic hyperplasias that fail to progress to melanoma over 15–20 monthsOn a Pten null background, these mice developed melanoma with 100% penetrance, short latency, and metastases (lymph nodes and lungs)Melanoma development was prevented by inhibitors of mTorc1 (rapamycin) or MEK1/2 (PD325901) but only whilst the drug was being administered (cessation of administration led to melanoma development). Combined rapamycin and PD325901 treatment led to shrinkage of established melanomas