In light of the fact that Vav1 is mutated in just 1% of 20427 cancer specimen analyzed, and in view of its complex biochemical structure and diverse cellular functions, it is prudent to await the identification of a larger number of mutations before we draw conclusions about the true identity of Vav1 mutants (oncogene/tumor suppressor gene), as suggested by Lawrence et al., who explored the feasibility of creating a comprehensive catalogue of cancer genes [102]. This evidence concerns the gene VAV1 and cancer.