Based on data recently obtained from human genome sequencing coordinated by the Wellcome Trust Sanger Institute, Vav1 appears to be mutated in ∼1% of human cancer of multiple tissue origins (Figure 1, http://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=Vav1&ln1=CBL&start=1&end=907&coords=AA%3AAA&sn=&ss=&hn=&sh=&id=5003#). The gene discussed is VAV1; the disease is cancer.