Although the physiological role of SREBP2 in maintaining cholesterol homeostasis is well defined, the importance of this basic helix-loop-helix leucine zipper transcription factor in cancer cells and oncogenesis remains relatively unexplored unlike that of SREBP1, which is highly activated in various cancers and its activation is linked with the PI3K/Akt/mTOR signalling axis [44–46]. Here, SREBF2 is linked to cancer.