Specifically, acute administration of non-selective CB1/CB2 receptor agonists CP55,940 (Colombo et al. 2002; Gallate et al. 1999; Vinod et al. 2008b) and WIN 55,212-2 (Alen et al. 2009; Colombo et al. 2002; Linsenbardt and Boehm 2009; Lopez-Moreno et al. 2004) decreased the development of alcohol CPP (Lopez-Moreno et al. 2004). Here, CNR1 is linked to alcohol dependence.