Thus the expression of transcription factor 4 (TCF4), enhancer of zeste homolog 2 (EZH2), DnaJ homolog subfamily B member 6 (DNAJB6) and histone deacetylase 2 (HDAC2) showed 2.0-, 3.0-, 1.6- and 2.3-fold increase, respectively, in the cisplatin refractory NSCLC clones relative to the corresponding untreated clones of replicate 1. Here, HDAC2 is linked to non-small cell lung carcinoma.