Notably, while cisplatin treatment or knockdown of DKK1 per se each reduced the colony formation capacity by up to 30 %, the combination of these treatments reduced colony formation by 50 % in U-1810 cells, demonstrating that DKK1 ablation sensitizes these NSCLC cells to cisplatin (Fig. 5c-d). This evidence concerns the gene DKK1 and non-small cell lung carcinoma.