Thus, according to OG/TSG theories there are a number of important molecules (and their associated pathways) that are the key players in cancer: Oncogenes such as RAS, MYC, EGFR, VEGFR, WNT, ERK, TRK, etc. Fusion oncoproteins such as BCR/ABL and tumor suppressors such as p53, BRCA, PTEN, CD95, and others. The gene discussed is TP53; the disease is cancer.