Evidence that intra-articular administration of adiponectin reduces the severity of collagen-induced arthritis in mouse [6], through modulation of tumour necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and matrix metalloproteinase (MMP)-3 in joint tissue, suggested that adiponectin may play a role in pain pathophysiology. This evidence concerns the gene ADIPOQ and Arthritis.