Hyal-1 showedsignificantly higher expression in basal cell hyperplasia than in moderate dysplasia(P=0.01), atypical adenomatous hyperplasia (P=0.0001), or severe dysplasia (P=0.03).Lower expression of Hyal-3 was found in atypical adenomatous hyperplasia than inbasal cell hyperplasia (P=0.01) or moderate dysplasia (P=0.02). Here, HYAL1 is linked to dysplasia.